ISSN 1849-9031 (Online)

ISSN 1849-8922    (Print)

Erythrocytosis and thrombocytosis secondary to hyperandrogenism caused by ovarian Leydig cell tumor.
Gorana Mirošević, Dražan Butorac, Ivan Kruljac, Milan Vrkljan.


Both erythroblasts and megakaryocytes contain androgen receptors, and testosterone regulates their expression. However, the exact mechanisms of testosterone’s hematopoietic effects are poorly understood. We report a case of perimenopausal women with severe hyperandrogenism caused by pure Leydig cell ovarian tumor accompanied by concomitant erythrocytosis and thrombocytosis. Substantial, immediate, and persistent decrease in both red blood cell count and platelet count after testosterone-secreting tumor removal in our patient suggests testosterone’s synergistic effect on erythropoiesis and thrombopoiesis. Further studies are worthy and might help to enlighten testosterone’s hematopoietic effects.