ISSN 1849-9031 (Online)

ISSN 1849-8922    (Print)

Relationship between insulin-like growth factor 2 and metabolic profile in women with polycystic ovary syndrome: A pilot study
Ivica Lazúrová, Zora Lazúrová, Jana Figurová, Silvia Toporcerová, Ingrid Dravecká, Miroslava Rabajdová, Jana Mašlanková.


Purpose: Insulin-like growth factor 2 (IGF2) is a widely expressed mitogenic peptide that may be involved in the pathogenesis of metabolic syndrome and polycystic ovary syndrome (PCOS). The aim of this pilot study was to compare serum IGF2 levels and IGF2 gene expression in non-obese PCOS women and those with higher body mass index (BMI) and to assess their relationship with metabolic and hormonal variables.

Methods: The study included 64 Caucasian women diagnosed with PCOS (ages 28.9 ± 5 years), 34 with BMI <27 and 30 with BMI >27 kg/m2. Parameters of glucose and lipid metabolism, steroid hormones, and serum IGF2 levels were recorded. Polymerase chain reaction (PCR) was used to assess mRNA IGF2 expression in 28 patients.

Results: No significant differences in serum IGF2 levels (P = 0.56) and mRNA IGF2 expression (P = 0.675) were found between non-obese PCOS women and those with higher BMI. There was a significant correlation between IGF2 and dihydrotestosterone (DHT) (R2 = 0.08, R2 adjusted = 0.07, P = 0.0222). There was no correlation between serum IGF2 and metabolic variables nor between IGF2 and other steroid hormones, but log mRNA IGF2 positively correlated with BMI (R2 = 0.14, R2 adjusted = 0.11, P = 0.0482), serum glucose (R2 = 0.23, R2 adjusted = 0.2, P = 0.0131), cholesterol (R2 = 0.29, R2 adjusted = 0.26, P = 0.0069), insulin (R2 = 0.48, R2 adjusted = 0.45, P = 0.0005), homeostasis model assessment insulin resistance (R2 = 0.46, R2 adjusted = 0.43, P = 0.0009), and total testosterone (TT) (R2 = 0.18, R2 adjusted = 0.15, P = 0.0257).

Conclusions: Serum IGF2 levels and IGF2 gene expression are not increased in obese PCOS women as compared to those with lower BMI. IGF2 positively correlated with DHT and log mRNA IGF2 positively correlated with serum glucose, insulin, cholesterol, and TT in PCOS women.