ISSN 1849-9031 (Online)

ISSN 1849-8922    (Print)

Obesity and blood cancers.
Djordje S. Popovic, Stevan L. Popovic, Edita Stokic, Lazar S. Popovic.


Obesity is the result of excessive accumulation of adipose tissue, and positive energy balance is the dominant cause of obesity. Obesity has reached pandemic proportions and represents a major global health issue. It contributes to the development of several major illnesses, including Type 2 diabetes, cardiovascular diseases, and various types of cancer. Excessive accumulation of visceral adipose tissue results in its altered secretory function. Hyperinsulinemia, lipid disorders, and chronic inflammation follow, providing an ideal environment for the initiation and promotion of cancer. Other disorders which are characteristic of obesity, such as alterations in the function of other endocrine systems and changes in microbiota, could also contribute to the elevated cancer risk. Hematological malignancies are forms of cancer originating from hematopoietic cells including cells of the immune system. Current data suggest a causal relationship between obesity and different forms of hematological malignancies. The major mechanisms linking obesity and blood cancers include changes in the secretion of adipokines and altered insulin, insulin-like growth factor-1, and lipid signalling, as well as dyslipidemia and increased inflammatory activity. Identifying and understanding the definite pathways connecting obesity with the onset and progression of different forms of hematological malignancies could enable the implementation of various therapeutic interventions including simple dietary modifications, utilization of wellknown drugs used for other diseases (metformin, statins, and non-steroidal anti-inflammatory drugs), as well as novel drugs directed against specific cellular targets.