ISSN 1849-9031 (Online)

ISSN 1849-8922    (Print)

Basic vitamin D concentration in multi-drug resistant tuberculosis patients in Latvia.
Sabīne Upmale, Rihards Engels, Līga Kukša.


Purpose: The primary goal of this study was to determine the basic concentration of vitamin D in patients with multidrug-resistant tuberculosis (MDR-TB) and its correlation with gender, age, and comorbidities.

Methods: This retrospective observational study comprised all adult patients diagnosed with active MDR-TB in Latvia during the period between January 2014 and December 2016. We analyzed patients’ anthropometric data, serum vitamin D concentrations, comorbidities, and laboratory findings at the time of diagnosis.

Results: Out of a total of 170 patients, 75.3% were male with a median age of 47 years. Vitamin D concentration was determined in 75 cases (44.1%). Out of them, 78.67% had vitamin D deficiency and 20% had insufficiency, while only 1.33% had optimal vitamin D concentration. The median concentration of vitamin D was 14.1 ng/ml (interquartile range 10.3-19.4). There was no statistically significant relationship between gender (F = 3.638, P = 0.060), age (r = −0.179, P = 0.124), or comorbidities (F = 0.677, P = 0.691) and vitamin D concentration.

Conclusion: Almost all MDR-TB patients have insufficient or deficient vitamin D concentrations. Therefore, it is recommended to assess vitamin D concentration in all MDR-TB patients to start proper substitution therapy.