ISSN 1849-9031 (Online)

ISSN 1849-8922    (Print)

Hormonal and adiposity state of women with polycystic ovary syndrome: implication of adiponectin and  leptin.
Aleksandra Atanasova Boshku, Sasha Jovanovska Mishevska, Beti Zafirova Ivanovska, Daniela Ivanova Panova.


Obesity and insulin resistance are frequently seen comorbidities in patients with polycystic ovary syndrome (PCOS), affecting the already disturbed metabolism of these patients. Disturbed secretion of adiponectin and leptin could be one of the contributing factors of obesity and insulin resistance in patients with PCOS. The aim of this study was to determine the levels of adiponectin and leptin in PCOS patients, as well as their association with other components of the syndrome. This cross-sectional study determined clinical, hormonal, and biochemical markers in 61 women with PCOS and 56 controls. There was a statistically significant difference in adiponectin and leptin between the groups (p>0.001). There was a significant negative correlation between adiponectin, body mass index (BMI), and waist circumference (r= -0.478; -0.452, p<0.001) and a negative correlation with testosterone, free androgen index (FAI), insulin, and the homeostasis model assessment for insulin resistance (HOMA-IR). A positive correlation between adiponectin, sex hormone binding globulin (SHGB), and fasting glucose levels was present. Correlation analysis of leptin with other metabolic parameters showed a positive correlation with BMI, waist circumference, insulin, and HOMA-IR. A significant inverse correlation was present between leptin and SHGB. In conclusion, adiponectin and leptin may serve as potential biomarkers of insulin resistance. Determining levels of adiponectin and leptin in the early course of this syndrome may enable earlier diagnosis of insulin resistance, or even early prevention in PCOS patients.