ISSN 1849-9031 (Online)

ISSN 1849-8922    (Print)

A diabetes free India by 2030.
Banshi Saboo, Sanjay Kalra, Shaukat Sadikot, A K Das, Usha Sriram, Shashank Joshi, B M Makkar, Jothydev Kesavadeva, Anuj Maheshwari, Dhruvi Hasnani, Sudhir Bhandari.

Abstract


In Indian scenario, the onset of diabetes pathogenesis begins at the fetal stage. The average newborn has a low birth weight but a high-fat percentage, the culprit being maternal malnutrition and metabolic dysfunction. The concept of the Asian Indian phenotype describes an Indian person with higher total and visceral fat compared to Caucasians. At a normal body mass index, the higher fat percentage might explain the faster beta cell function failure and early development of diabetes. To achieve the aim, we must work toward creating a salutogenic phenotype and environment. This can be done by focusing on girls at the prepubertal stage. If they grow into healthy adolescents and women, they will become healthy mothers. By 2030, they will have healthy children, who will be less likely to develop diabetes. Understanding these circumstances, the Honorable President of India, Shri Pranab Mukherjee, recently called for a diabetes-free India by 2030. While the diabetogenic environment has been discussed at length by experts, here we focus on how to improve our phenotype since we believe that the origin of diabetes begins with phenotype rather than the environment. Thus, focusing on a healthy phenotype, right from the start of life (in utero) might have a beneficial impact on transgenerational “transmission” of diabetes. To prevent diabetes in the future, we need to ensure that our children are born with a healthy phenotype and are provided with an adequate environment.